As with most 4-koma anime adaptions, there isn't a deep underlying story to Yuyushiki. It simply tells the story of the everyday life of Yuzuko, Yukari and Yui, who are three members of their school's data processing club. They get together and talk about all sorts of things in adorable ways.
- Ichii Yui [櫟井唯] played by Tsuda Minami [津田美波]
- Nonohara Yuzuko [野々原ゆずこ] played by Ookubo Rumi [大久保瑠美]
- Hinata Yukari [日向縁] played by Taneda Risa [種田梨沙]
The official website for the show can be found here.
There isn't a special character page yet, but the website is likely to be updated soon with more information and character descriptions.
The opening theme is "Se~no!" [せーのっ!] and will be sung by the voice actors for the three main characters in the show.
These screenshots come from the trailer seen above.
Here are some other images from the show found by asking Google Sensei.